[PHNUTR-L] Novel interactions of vitamin e and estrogen in breast
Kathrynne Holden, MS, RD
fivestar at nutritionucanlivewith.com
Wed Aug 17 09:47:30 PDT 2005
Colleagues, the following is FYI and does not necessarily reflect my own
opinion. I have no further knowledge of the topic.
Nutr Cancer. 2005;52(1):43-8.
Novel interactions of vitamin e and estrogen in breast cancer.
Chamras H, Barsky SH, Ardashian A, Navasartian D, Heber D, Glaspy JA.
The prevention of breast cancer through dietary modification is an
active area of clinical and epidemiological research. It has been
proposed that dietary supplementation of vitamin E may reduce a woman's
risk of developing breast cancer. However, the exact mechanism remains
unknown. alpha-Tocopherol is the most biologically active form of
vitamin E. We investigated the effect of vitamin E (alpha-tocopherol) on
breast cancer cell growth. A dose-dependent inhibition of cell
proliferation was found in estrogen receptor (ER)-positive cells showing
a potent suppression of growth at 100 muM vitamin E in MCF-7 (53%) and
T47D (75%) cells. Vitamin E reduced significantly the response of both
cell lines to estrogen (10 nM), and cell proliferation was decreased in
MCF-7 and T47D cells by 69% and 84%, respectively. No growth inhibition
was observed when cells were grown in the absence of estrogen. Vitamin E
altered and decreased the growth inhibition induced by tamoxifen (10
muM) in MCF-7 (33%) and T47D (54%) cells. In addition, the
immunostaining of ER of MCF-7 cells was reduced by 30% in the presence
of vitamin E, suggesting an effect of vitamin E on the expression of ER.
This provides evidence that vitamin E may inhibit ER-positive cell
growth by altering the cellular response to estrogen.
PMID: 16091003 [PubMed - in process]
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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