[PHNUTR-L] Why dieting mothers have fat kids
jikeda at berkeley.edu
Tue Aug 30 10:47:53 PDT 2005
>Public release date: 7-Jun-2005
>Contact: Heidi Hardman
><mailto:hhardman at cell.com>hhardman at cell.com
>Link between mothers' poor diets, kids' obesity
>New work may have found the missing link between mothers' diets and
>obesity in kids. A study published in the June issue of Cell Metabolism
>suggests that a hormone may explain the connection between mothers who are
>poorly nourished and an increased risk of obesity in their children.
>The study reports evidence that a premature surge of the hormone leptin in
>newborn mice of underfed mothers leads to a remodeling of key brain
>circuits that contributes to obesity in the animals later in life.
>Moreover, the researchers found that the early leptin surge alone was
>enough to cause the accelerated weight gain.
>The findings offer one mechanism whereby metabolic disease can originate
>from early developmental experiences, the researchers said.
>"Obesity has increased at an alarming rate in Western countries and is now
>a worldwide public health problem," said Shingo Fujii of the Kyoto
>University Graduate School of Medicine in Japan. "Genetic and
>environmental factors, such as a high-calorie diet, are thought to
>contribute to the prevalence of obesity.
>"The present study suggests that a premature surge of leptin as a result
>of fetal undernourishment can alter energy regulation by the brain and
>contribute to developmental origins of health and disease."
>Leptin is a hormone produced by fat that normally decreases food intake
>and increases energy expenditure. In many species, including humans, the
>hormone acts to stabilize weight and glucose balance through its effects
>on leptin receptors in a portion of the brain called the hypothalamus.
>Earlier studies have found that mice lacking leptin show marked obesity
>that is restored following leptin treatment. However, obese animals often
>exhibit resistance to leptin's usual effects and high blood concentrations
>of the hormone.
>Evidence has also suggested that a neonatal surge of leptin may play an
>important role in the formation of energy-regulating brain circuits in the
>In the new study, mice born of mothers who ate 30 percent less than normal
>were small at birth and had less fat. However, the undernourished newborns
>caught up with normal mice after ten days and, when fed a high-fat diet,
>developed pronounced weight gain and increased leptin levels compared to
>normal mice on the same diet.
>The undernourished mice had lower body temperatures than normal mice,
>suggesting that the prenatal nutritional deficiency "programmed" them to
>conserve energy, the researchers said. During the catch-up growth period,
>the transient rise in leptin levels normally seen in newborns occurred six
>to eight days earlier in undernourished animals.
>When the researchers mimicked that premature leptin surge by administering
>the hormone to normally fed mice, those animals also became prone to
>obesity upon eating a diet high in fat.
>"Unexpectedly, normal offspring treated with leptin as newborns were
>indistinguishable from those that were undernourished before birth," Fujii
>said. "Premature onset of leptin surge is thus causally related to
>pronounced obesity in undernourished offspring on a high-fat diet."
>The researchers further demonstrated that the mice experiencing a
>premature surge of fat hormone exhibited resistance to administered
>leptin, with impaired transport of the hormone to the brain and
>abnormalities in the hypothalamic brain region that governs leptin
>response. The findings suggest that the leptin surge may be a target for
>therapeutic intervention in the developmental origins of health and
>disease, the researchers said.
>The researchers include Shigeo Yura, Hiroaki Itoh, Norimasa Sagawa,
>Hiroaki Masuzaki, Kazuwa Nakao, Makoto Kawamura, Maki Takemura, Kazuyo
>Kakui, and Shingo Fujii of Kyoto University Graduate School of Medicine;
>Hiroshi Yamamoto of Shiga University of Medical Science; and Yoshihiro
>Ogawa of Tokyo Medical and Dental University. This work was supported in
>part by Grants-In-Aid for the Scientific Research from the Ministry of
>Education, Science, and Culture, Japan and by grants from the Ministry of
>Health and Welfare, the Smoking Research Foundation, the Mitsui Sumitomo
>Insurance Welfare Foundation, Astellas Foundation for Research on
>Metabolic Disorders, Ono Medical Research Foundation, and Daiwa Securities
>Yura, S., Itoh, H., Sagawa, N., Yamamoto, H., Masuzaki, H., Nakao, K.,
>Kawamura, M., Takemura, M., Kakui, K., Ogawa, Y., and Fujii, S. (2005).
>Role of premature leptin surge in obesity resulting from intrauterine
>undernutrition. Publishing in Cell Metabolism, June, 2005, Vol. 1, pages
>371-378. DOI 10.1016/j.cmet.2005.05.005
>YAHOO! GROUPS LINKS
> * Visit your group "<http://groups.yahoo.com/group/shaes>shaes" on
> the web.
> * To unsubscribe from this group, send an email to:
> <mailto:shaes-unsubscribe at yahoogroups.com?subject=Unsubscribe>shaes-unsubscribe at yahoogroups.com
> * Your use of Yahoo! Groups is subject to the
> <http://docs.yahoo.com/info/terms/>Yahoo! Terms of Service.
Joanne P. Ikeda, MA,RD
Cooperative Extension Nutrition Education Specialist & Lecturer
223 Morgan Hall
Nutritional Sciences Department
University of California
Berkeley, CA 94720-3104
email: jikeda at berkeley.edu
^^^Please note this is a new email address.
See website of the Center for Weight and Health: http://cnr.berkeley.edu/cwh
-------------- next part --------------
A non-text attachment was scrubbed...
Size: 34723 bytes
Desc: not available
Url : http://mailman2.u.washington.edu/pipermail/phnutr-l/attachments/20050831/8ac85b31/6613a7-0001.jpg
More information about the PHNUTR-L