[PHNUTR-L] Relationship between fasting serum glucose, age, BMI and serum 25 hydroxyvitamin D in postmenopausal women

[Kathrynne Holden, MS, RD]

Colleagues, the following is FYI and does not necessarily reflect my own
opinion. I have no further knowledge of the topic.
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Clin Endocrinol (Oxf). 2005 Jun;62(6):738-41. 	
     Relationship between fasting serum glucose, age, body mass index 
and serum 25 hydroxyvitamin D in postmenopausal women.

     Need AG, O'loughlin PD, Horowitz M, Nordin BE.

     Division of Clinical Biochemistry, Institute of Medical and 
Veterinary Science, University of Adelaide, Adelaide, SA, Australia.

     Summary
Objective Because it has been reported that vitamin D, given to mother 
or infant, can prevent type I diabetes in children, that diabetes is 
more common in adults with low serum vitamin D and that insulin 
secretion and action are related to vitamin D levels in healthy young 
adults we examined the relationship between serum vitamin D metabolites 
and fasting serum glucose in patients attending our outpatient clinics. 
Design
Retrospective examination of convenience sample of postmenopausal women 
attending our osteoporosis clinics.
Patients
A total of 753 postmenopausal women attending a university hospital 
outpatient clinic and not on any treatment known to affect glucose 
metabolism.
Measurements
Body weight and height, serum 25-hydroxyvitamin D [25(OH)D], serum 
1,25-dihydroxyvitamin D [1,25(OH)(2)D], serum PTH and fasting serum 
glucose.
Results
On simple correlation fasting serum glucose was a positive function of 
age (P < 0.05), weight (P < 0.001) and body mass index (BMI) (P < 0.001) 
and a negative function of serum 25(OH)D (P < 0.001), but it was not 
significantly related to either serum 1,25(OH)(2)D, PTH or creatinine. 
When fasting serum glucose was regressed simultaneously on age, BMI and 
25(OH)D, glucose was still an inverse function of 25(OH)D (P = 0.006). 
Conclusions
Fasting serum glucose increased as 25(OH)D levels fell throughout the 
range of serum 25(OH)D measured but the greatest increase was observed 
in those with 25(OH)D below 40 nmol/l.

     PMID: 15943837 [PubMed - in process]
-- 
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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