[PHNUTR-L] Low levels of vitamin B and venous thromboembolic
disease in elderly men
Kathrynne Holden, MS, RD
fivestar at nutritionucanlivewith.com
Fri Sep 2 06:57:11 PDT 2005
Colleagues, the following is FYI and does not necessarily reflect my own
opinion. I have no further knowledge of the topic.
J Intern Med. 2005 Sep;258(3):244-9.
Low levels of vitamin B and venous thromboembolic disease in
Diaz DE Tuesta AM, Ribo MD, Belinchon O, Marchena PJ, Bruscas MJ,
Val E, Cortes A, Nieto JA.
Department of Internal Medicine, Virgen de al Luz Hospital, Cuenca,
Objectives. Hyperhomocysteinaemia is a well-known risk factor for
venous thromboembolic disease (VTD). However, it is not clear whether
homocysteine (Hc) itself or a related metabolite or a cofactor is
primarily responsible for VTD. We carried out a case-control study to
investigate whether vitamin concentrations that are involved in the Hc
metabolism are associated or not with an elevated risk of VTD. Design.
Case-control study. Methods. We measured serum vitamin B(12), folate,
creatinine and albumin concentrations and plasma Hc concentrations in
101 consecutive patients with VTD, diagnosed by image tests and 101
control subjects, matched for age and sex. Results. Serum vitamin B(12)
concentrations were significantly lower in VTD patients than in the
control subjects. There were no differences in plasma Hc or serum folate
concentrations between the groups. Among the male subgroup aged more
than 70 years, serum vitamin B(12) concentrations were significantly
lower (240.88 +/- 103.07 vs. 421.20 +/- 314.31 pmol L(-1); P = 0.03) and
plasma Hc concentrations were significantly higher (13.1 +/- 4.18 vs.
10.56 +/- 3.06 mumol L(-1); P =0.04) in VTD patients than in the control
group. On multivariate analysis, in patients aged more than 70 years,
serum vitamin B(12) concentrations were independently associated with
VTD. Compared with the highest quartile of vitamin B(12) (>512.6 pmol
L(-1)) the odds ratio (OR) for VTD in the lowest quartile (<230.9 pmol
L(-1)) was 3.8 (95% CI 1.44-10.18; P = 0.01). In the VTD group, lowest
vitamin B(12) concentrations (percentile 10 <152.8 pmol L(-1)) were
associated with the factor V Leiden mutation (OR = 6.07, 95% CI
0.93-38.55; P = 0.04). Conclusions. Measuring vitamin B(12)
concentrations in elderly males may help in identifying people at risk
of venous thromboembolism in our population.
PMID: 16115298 [PubMed - in process]
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
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