[PHNUTR-L] Consumption of soy may reduce risk of fracture in
Kathrynne Holden, MS, RD
fivestar at nutritionucanlivewith.com
Tue Sep 13 06:59:57 PDT 2005
Colleagues, the following is FYI and does not necessarily reflect my own
opinion. I have no further knowledge of the topic.
Public release date: 12-Sep-2005
Contact: Clinton Colmenares
JAMA and Archives Journals
Consumption of soy may reduce risk of fracture in postmenopausal women
CHICAGO – Postmenopausal women who consumed high daily levels of soy
protein had reduced risk of bone fracture, according to a study in the
September 12 issue of Archives of Internal Medicine, one of the
Women experience accelerated bone loss at a rate of three to five
percent per year for about five to seven years after menopause, putting
them at a high risk for bone fracture, according to background
information in the article. The U.S. Food and Drug Administration and
new clinical guidelines advise against the use of hormone therapy as a
first-line treatment for the prevention of osteoporosis in
postmenopausal women and emphasize alternatives including exercise and
increasing intake of calcium and vitamin D. Growing evidence suggests a
potential role for soy in preventing postmenopausal bone loss.
Xianglan Zhang, M.D., M.P.H., from the Vanderbilt University School of
Medicine, Nashville, and colleagues examined the relationship between
soy food consumption and bone fractures in 24,403 postmenopausal women.
The women were part of the Shanghai Women's Health Study, a study of
approximately 75,000 Chinese women aged 40 to 70 years, conducted
between March 1997 and May 2000. Participants' usual dietary intake was
assessed once at the beginning of the study and then during follow-up,
approximately two to three years later. Average age was 60 years.
The researchers found that soy consumption may reduce the risk of
fracture in postmenopausal women, especially among those in the early
years following menopause. During an average follow-up of four and a
half years, 1,770 fractures were reported. The median (middle value)
daily intakes of soy protein and soy isoflavones (estrogen-like plant
chemicals) were 8.5 grams and 38 micrograms, respectively. Participants
were divided into five categories, according to their soy intake, with
the lowest intake group consuming less than 4.98 grams of soy per day,
and the highest group consuming 13.27 grams or more of soy per day.
Those in the highest soy protein intake group had a 37 percent reduced
relative risk for fracture compared to the lowest intake group. Women in
the highest soy isoflavone group had a 35 percent reduced relative risk
for fracture compared to the lowest isoflavone group.
"In this prospective cohort study of postmenopausal women, we found that
soy food consumption was associated with a significantly lower risk of
fracture, particularly among women in the early years following
menopause," the researchers write. "The potential impact of timing on
the skeletal effects of soy needs to be further addressed in future
(Arch Intern Med. 2005; 165: 1890 – 1895. Available pre-embargo to media
Editor's Note: This study was supported by a research grant from the
National Institutes of Health, Bethesda, Md.
For more information, contact JAMA/Archives Media Relations at
312-464-JAMA (5262) or email mediarelations at jama-archives.org.
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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