[PHNUTR-L] Dietary Patterns and Risk of Colorectal Tumors

[Kathrynne Holden]

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	Dietary Patterns and Risk of Colorectal Tumors
http://www.nutritionucanlivewith.com

Reference: 	“Dietary Patterns and Risk of Colorectal Tumors: A Cohort of 
French Women of the National Education System (E3N),” Kesse E, 
Clavel-Chapelon F, Boutron-Ruault MC, Am J Epidemiol., 2006 Sep 21; 
[Epub ahead of print]. (Address: Inserm, ERI20, Equipe E3N, Institut 
Gustave Roussy, Villejuif Cedex, France. E-Mail: boutron at igr.fr ).

Summary: 	In a prospective French cohort study involving 67,312 
cancer-free women, 172 women with colorectal cancer, 4,804 polyp-free 
women, and 516 women with adenomas (175 with high-risk adenomas), the 
authors conclude, “Dietary patterns that reflect a Western way of life 
[high in fats, animal products, and snacks, and low in fruits and 
vegetables] are associated with a higher risk of colorectal tumors.” 
Four dietary patterns were identified in the cohort: 1) “healthy” – 
vegetables, fruit, yogurt, seafood, and olive oil; 2) “Western” – 
potatoes, pizzas and pies, sandwiches, sweets, cakes, cheese, cereal 
products, processed meats, eggs, and butter; 3) “drinker” – sandwiches, 
snacks, processed meats, and alcoholic beverages; 4) “meat eaters” – 
meat, poultry, and margarine. Factor analysis was used to obtain subject 
scores for dietary patterns. After adjusting for daily energy intake, 
BMI, physical activity level, smoking status, family history of 
colorectal cancer, and education, wo men in the highest quartiles of 
factor scores for the “Western” and “drinker” dietary patterns had a 39% 
and 42% increased risk of adenoma, respectively, compared to women in 
the corresponding lowest quartiles. On the other hand, women in the 
highest quartile of factor scores for the “healthy” dietary pattern 
showed a weak, nonsignificant decrease in adenoma risk (relative risk, 
0.85), compared to women in the lowest quartile. Additionally, women in 
the highest quartiles of factor scores for the “meat eaters” and 
“drinker” dietary patterns showed a 58% and 36% increased risk of 
colorectal cancer, respectively, compared to women in the corresponding 
lowest quartiles, whereas, women in the highest quartile of factor 
scores for the “healthy” dietary pattern showed a 23% reduced risk of 
colorectal cancer, compared to women in the lowest quartile. Thus, the 
results of this study involving a cohort of French women suggest that 
dietary patterns associated with a Western way of l! ife are associated 
with an increased risk of colorectal tumors.
-- 
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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