[PHNUTR-L] Change in lipid profile in celiac disease: beneficial
effect of gluten-free diet
Kathrynne Holden, MS, RD
fivestar at nutritionucanlivewith.com
Tue Sep 12 19:28:37 PDT 2006
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Am J Med. 2006 Sep;119(9):786-90.
Change in lipid profile in celiac disease: beneficial effect of
Brar P, Kwon GY, Holleran S, Bai D, Tall AR, Ramakrishnan R, Green PH.
Department of Medicine, Columbia University College of Physicians
and Surgeons, New York, NY, USA.
PURPOSE: Celiac disease is associated with hypocholesterolemia,
which is thought to contribute to a favorable cardiovascular risk
profile. This led to suggestions that the diagnosis of celiac disease
and its treatment with a gluten-free diet may result in elevation of the
serum cholesterol level and worsen this risk profile. However, no study
proves this in adults. We therefore examined the effect of a gluten-free
diet on the lipid profile in patients with celiac disease. SUBJECTS AND
METHODS: We identified 132 patients with celiac disease who adhered to a
gluten-free diet and had lipid profiles performed before and after a
median of 20.5 months on the diet. The patients lacked diseases that may
affect serum lipids. RESULTS: There were significant increases in total
cholesterol and high-density lipoprotein (HDL) cholesterol (P < .0001)
but not low-density lipoprotein (LDL) cholesterol (P=.06). The LDL/HDL
ratio decreased by 0.36+/-0.7 (P < .0001). Both men and women had a
significant increase in total cholesterol and HDL and a significant
decrease in the LDL/HDL ratio. Only men had increases in LDL (P=.02).
The greatest increase in lipid values was seen in those with the lowest
initial values. The largest increase in HDL was seen in subjects with
more severe disease as indicated by low albumin level and presence of
total villous atrophy. CONCLUSIONS: Diagnosis of celiac disease and its
treatment with a gluten-free diet resulted in improvement in the
lipoprotein profile, which included an increase in HDL and a decrease in
the LDL/HDL ratio.
PMID: 16945614 [PubMed - in process]
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
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