[PHNUTR-L] Change in lipid profile in celiac disease: beneficial effect of gluten-free diet

[Kathrynne Holden, MS, RD]

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  Am J Med. 2006 Sep;119(9):786-90. 	
     Change in lipid profile in celiac disease: beneficial effect of 
gluten-free diet.

     Brar P, Kwon GY, Holleran S, Bai D, Tall AR, Ramakrishnan R, Green PH.

     Department of Medicine, Columbia University College of Physicians 
and Surgeons, New York, NY, USA.

     PURPOSE: Celiac disease is associated with hypocholesterolemia, 
which is thought to contribute to a favorable cardiovascular risk 
profile. This led to suggestions that the diagnosis of celiac disease 
and its treatment with a gluten-free diet may result in elevation of the 
serum cholesterol level and worsen this risk profile. However, no study 
proves this in adults. We therefore examined the effect of a gluten-free 
diet on the lipid profile in patients with celiac disease. SUBJECTS AND 
METHODS: We identified 132 patients with celiac disease who adhered to a 
gluten-free diet and had lipid profiles performed before and after a 
median of 20.5 months on the diet. The patients lacked diseases that may 
affect serum lipids. RESULTS: There were significant increases in total 
cholesterol and high-density lipoprotein (HDL) cholesterol (P < .0001) 
but not low-density lipoprotein (LDL) cholesterol (P=.06). The LDL/HDL 
ratio decreased by 0.36+/-0.7 (P < .0001). Both men and women had a 
significant increase in total cholesterol and HDL and a significant 
decrease in the LDL/HDL ratio. Only men had increases in LDL (P=.02). 
The greatest increase in lipid values was seen in those with the lowest 
initial values. The largest increase in HDL was seen in subjects with 
more severe disease as indicated by low albumin level and presence of 
total villous atrophy. CONCLUSIONS: Diagnosis of celiac disease and its 
treatment with a gluten-free diet resulted in improvement in the 
lipoprotein profile, which included an increase in HDL and a decrease in 
the LDL/HDL ratio.

     PMID: 16945614 [PubMed - in process]
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