[PHNUTR-L] Higher Content of Polyphenols in Red Wine Makes it More Antioxidant than White Wine

[Kathrynne Holden, MS, RD]

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	Higher Content of Polyphenols in Red Wine Makes it More Antioxidant 
than White Wine
http://www.vitasearch.com/CP/weeklyupdates/

Reference: 	“Polyphenols synergistically inhibit oxidative stress in 
subjects given red and white wine,” Pignatelli P, Ghiselli A, et al, 
Atherosclerosis, 2006; 188(1): 77-83. (Address: Universita di Roma La 
Sapienza, Divisione IV Clinica Medica, Policlinico Umberto I, Viale del 
policlinico, 00185 Rome, Italy).

Summary: 	In a study involving 30 healthy subjects, the results led the 
authors to conclude, “red wine is more antioxidant than white wine, in 
virtue of its higher content of polyphenols, an effect that may be 
dependent upon a synergism among polyphenols.” In the in vivo arm of the 
study, subjects were randomized to receive 300 ml of red wine (n=10; red 
wine group), 300 ml of white wine (n=10; white wine group), or no wine 
(n=10; controls), for a period of 15 days. A significant reduction in 
urinary PGF-2alpha-III levels (marker of oxidative stress) was observed 
in both the red (38.5%) and white wine (23.1%) groups, with a greater 
reduction found in the red wine group. Additionally, subjects in the red 
wine group had higher plasma polyphenols (1.9 microM) than those in the 
white wine group (1.5 microM). An inverse association was found between 
plasma polyphenols and urinary PGF2alpha. No changes in urinary 
isoprostanes were observed in the controls. In the in vitro arm of the 
stu dy, only a mixture of polyphenols – all in a range corresponding to 
that found in human circulation – inhibited LDL oxidation and 
PKC-mediated NADPH oxidase activation. The inhibitory effects were more 
pronounced at concentrations of polyphenols similar to that detected in 
human circulation after red wine intake. Thus, this study suggests that 
while both red and white wine intake may inhibit oxidative stress, the 
antioxidant
-- 
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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