[PHNUTR-L] Plant Lignans Associated with Lower Breast Cancer Risk
among Postmenopausal Women
fivestar at nutritionucanlivewith.com
Wed Apr 18 09:40:55 PDT 2007
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High Dietary Intake of Plant Lignans is Associated with Lower Breast
Cancer Risk among Postmenopausal Women
Reference: "Dietary lignan intake and postmenopausal breast cancer risk
by estrogen and progesterone receptor status," Touillaud MS,
Clavel-Chapelon F, et al, J Natl Cancer Inst, 2007; 99(6): 475-86.
(Address: Institut National de la Sante et de la Recherche Medicale, ERI
20, Institut Gustave-Roussy, 39 rue Camille Desmoulins, 94805 Villejuif
Cedex, France. E-Mail: clavel at igr.fr ).
Summary: In a prospective study involving 58,049 postmenopausal French
women not taking soy isoflavone supplements, high dietary intake of
plant lignans and high exposure to enterolignans (when consumed, lignans
are metabolized by intestinal bacteria and converted to the
enterolignans - enterodiol and enterolactone) were associated with
reduced risks of ER (estrogen receptor)- and PR (progesterone
receptor)-positive breast cancer. During a median follow-up of 7.7
years, 1,469 cases of breast cancer were diagnosed. Using Cox
proportional hazards regression models adjusted for potential
confounders, women in the highest quartiles of total lignan intake (>
1395 microg/day) and lariciresinol intake (a plant lignan) showed 17%
and 18% reduced risks for breast cancer, respectively, compared to women
in the corresponding lowest quartiles of intake. Additionally, the
highest quartile of total plant lignan intake was associated with a 28%
reduced risk for ER- and PR-positive breast cancer, compared to the
lowest quartile of intake. Similarly, the highest quartile of total
enterolignan levels was associated with a 23% reduced risk for ER- and
PR-positive breast cancer, compared to the lowest quartile. Thus, the
authors of this study conclude, "High dietary intakes of plant lignans
and high exposure to enterolignans were associated with reduced risks of
ER- and PR-positive postmenopausal breast cancer in a Western population
that does not consume a diet rich in soy."
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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