[PHNUTR-L] Plant Lignans Associated with Lower Breast Cancer Risk among Postmenopausal Women

[Kathrynne Holden]

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High Dietary Intake of Plant Lignans is Associated with Lower Breast 
Cancer Risk among Postmenopausal Women
http://www.vitasearch.com/CP/weeklyupdates/

Reference: 	"Dietary lignan intake and postmenopausal breast cancer risk 
by estrogen and progesterone receptor status," Touillaud MS, 
Clavel-Chapelon F, et al, J Natl Cancer Inst, 2007; 99(6): 475-86. 
(Address: Institut National de la Sante et de la Recherche Medicale, ERI 
20, Institut Gustave-Roussy, 39 rue Camille Desmoulins, 94805 Villejuif 
Cedex, France. E-Mail: clavel at igr.fr ).
Summary: 	In a prospective study involving 58,049 postmenopausal French 
women not taking soy isoflavone supplements, high dietary intake of 
plant lignans and high exposure to enterolignans (when consumed, lignans 
are metabolized by intestinal bacteria and converted to the 
enterolignans - enterodiol and enterolactone) were associated with 
reduced risks of ER (estrogen receptor)- and PR (progesterone 
receptor)-positive breast cancer. During a median follow-up of 7.7 
years, 1,469 cases of breast cancer were diagnosed. Using Cox 
proportional hazards regression models adjusted for potential 
confounders, women in the highest quartiles of total lignan intake (> 
1395 microg/day) and lariciresinol intake (a plant lignan) showed 17% 
and 18% reduced risks for breast cancer, respectively, compared to women 
in the corresponding lowest quartiles of intake. Additionally, the 
highest quartile of total plant lignan intake was associated with a 28% 
reduced risk for ER- and PR-positive breast cancer, compared to the 
lowest quartile of intake. Similarly, the highest quartile of total 
enterolignan levels was associated with a 23% reduced risk for ER- and 
PR-positive breast cancer, compared to the lowest quartile. Thus, the 
authors of this study conclude, "High dietary intakes of plant lignans 
and high exposure to enterolignans were associated with reduced risks of 
ER- and PR-positive postmenopausal breast cancer in a Western population 
that does not consume a diet rich in soy."
-- 
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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