[PHNUTR-L] High Serum Selenium Levels Linked to Increased Diabetes
fivestar at nutritionucanlivewith.com
Sun Apr 29 12:56:18 PDT 2007
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High Serum Selenium Levels Linked to Increased Diabetes Risk
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NEW YORK (Reuters Health) Apr 19 - Contrary to expectation, high serum
selenium levels are positively associated with the prevalence of
diabetes, according to findings published in the April issue of Diabetes
"Oxidative stress reduces insulin secretion and increases insulin
resistance in some experimental models and thus play a causal role in
the pathogenesis of diabetes," write Dr. Joachim Bleys and colleagues
from Johns Hopkins University Bloomberg School of Public Health,
Baltimore, Maryland. "Because of its antioxidant properties, selenium
might thus prevent the development of diabetes."
To test their hypothesis that selenium levels would be inversely
associated with diabetes prevalence, the researchers conducted a
cross-sectional analysis of data from 8876 subjects (at least 20 years
of age) who participated in the Third National Health and Nutrition
The team defined diabetes as a fasting plasma glucose of at least 126
mg/dL, a self-report of a physician diagnosis of diabetes, or current
use of insulin or oral hypoglycemic medication. Atomic absorption
spectrometry was used to measure serum selenium.
The results ran counter to what was anticipated. After adjustment for
age, sex, race, and body mass index, serum selenium levels were 126.8
ng/mL and 124.7 ng/mL in diabetic and non-diabetic subjects,
respectively (adjusted difference 2.1 ng/mL; p = 0.02).
The multivariate-adjusted odds ratio for diabetes for the highest versus
the lowest quintile of serum selenium was 1.57.
The authors call for prospective studies with diabetes incidence as the
outcome in order to establish a causal role of selenium on the risk of
"Until the findings of these studies are available, selenium intake,
including selenium supplementation, should not be recommended for
diabetes prevention in populations with adequate selenium status," Dr.
Bleys and colleagues advise. "Furthermore, diabetic patients should
avoid selenium supplementation until randomized controlled trials show
objective benefits on mortality or morbidity end points."
Diabetes Care 2007;30:829-834.
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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