[PHNUTR-L] Eating a Fat-Rich Meal Positively Affects Postprandial Early Insulin Secretion in Type 2 Diabetic Postmenopausal Women

[Kathrynne Holden]

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	Eating a Fat-Rich Meal Positively Affects Postprandial Early Insulin 
Secretion in Type 2 Diabetic Postmenopausal Women
http://www.vitasearch.com/CP/weeklyupdates/

Reference: 	"Meal Composition affects insulin secretion in women with 
type 2 diabetes: a comparison with healthy controls. The Hoorn prandial 
study," Alssema M, Dekker JM, et al, Eur J Clin Nutr, 2007 Nov 7; [Epub 
ahead of print]. (Address: EMGO Institute, VU University Medical Center, 
Amsterdam, The Netherlands. E-mail: m.alssema at vumc.nl ).

Summary: 	In a study involving 76 normoglycemic and 64 type 2 diabetic 
postmenopausal women, results indicate that consumption of a fat-rich 
mixed meal may be associated with a higher insulinogenic index - a 
measure of early insulin secretion following a meal - compared to 
consumption of a carbohydrate-rich mixed meal, in type 2 diabetic women. 
The participants received a fat-rich and carbohydrate-rich meal on 
separate occasions. Normoglycemic women presented with higher 
insulinogenic index than type 2 diabetic women. Insulinogenic index 
following the fat-rich meal was higher than that after the 
carbohydrate-rich meal (not significant in normoglycemic women). In type 
2 diabetic women, homeostasis model assessment for insulin resistance 
was positively associated with insulinogenic index following the 
carbohydrate-rich meal. Additionally, in normoglycemic women, an 
independent inverse association was observed between waist circumference 
and insulinogenic index following the carbohydr ate-rich and fat-rich 
meals. Thus, the authors of this study conclude, "The insulinogenic 
index following the fat-rich meal was higher than following the 
isocaloric carbohydrate-rich meal, which might favorably affect 
postprandial glucose excursions, especially in women with type 2 
diabetes. The association between a larger waist circumference and a 
lower meal-induced insulinogenic index in normoglycemic women requires 
further mechanistic studies."
-- 
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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