[PHNUTR-L] Risk of Parkinson's disease increases with pesticide
exposure and head trauma
fivestar at nutritionucanlivewith.com
Fri Jun 1 07:34:06 PDT 2007
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Public release date: 29-May-2007
Contact: Rebecca Spargo
rspargo at bma.org.uk
BMJ Specialty Journals
Risk of Parkinson's disease increases with pesticide exposure and head
Environmental risk factors for Parkinson's disease and Parkinsonism: the
Exposure to pesticides and traumatic head injury may have a causative
role in Parkinson's disease, according to a study published online ahead
of print in the journal Occupational and Environmental Medicine.
And the risk of developing Parkinson's disease increases according to
the level of exposure, the results showed.
The two risk factors are potentially modifiable, the authors say. Head
trauma resulting from contact sports such as boxing can be avoided and
further research could identify more specifically which pesticides are
associated with this effect, so that these agents can be substituted.
People who had been exposed to low levels of pesticides were found to be
1.13 times as likely to have Parkinson's disease compared with those who
had never been exposed. Those who had been exposed to high levels of
pesticides were 1.41 times as likely to be affected.
Parkinson's disease occurred 1.35 times more frequently in people who
had been knocked unconscious once compared with those who had never been
knocked out, and arose 2.53 times more frequently in those who had been
knocked out more frequently.
The European Commission funded study is one of the largest case-control
studies to date of genetic, environmental and occupational risk factors
for Parkinson's disease or other degenerative parkinsonian syndromes. It
involved 959 prevalent cases of parkinsonism (767 with Parkinson's
disease) and 1989 controls recruited in Scotland, Italy, Sweden, Romania
Cases were defined using the UK Parkinson's Disease Society Brain Bank
criteria. Patients with drug-induced or vascular parkinsonism or
dementia were excluded.
Subjects completed a questionnaire regarding their lifetime occupational
and recreational exposure to solvents, pesticides, iron, copper and
manganese. Their lifetime exposure was then estimated blind to disease
status and the results were adjusted, as appropriate, for age, sex,
country of residence, tobacco use, ever having been knocked unconscious
and family history of Parkinson's disease.
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
"Eat well, stay well with Parkinson's disease"
"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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