[PHNUTR-L] Mg deficiency induces heart rhythm changes,
impairs glucose tolerance,
decreases serum cholesterol in post menopausal women
fivestar at nutritionucanlivewith.com
Wed Jun 6 07:11:30 PDT 2007
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J Am Coll Nutr. 2007 Apr;26(2):121-32.
Dietary magnesium deficiency induces heart rhythm changes, impairs
glucose tolerance, and decreases serum cholesterol in post menopausal women.
Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L.
USDA, ARS, Grand Forks Human Nutrition Research Center, PO Box
9034, Grand Forks, ND, 58202-9034. fnielsen at gfhnrc.ars.usda.gov.
OBJECTIVE: To determine whether or not dietary magnesium
restriction to about 33% of the Recommended Dietary Allowance (RDA)
causes changes in glucose, cholesterol and electrolyte metabolism that
could lead to pathologic consequences. DESIGN: The length of the
experiment was 136 days. Subjects were fed a basal Western-type diet
that provided 4.16 mmol (101 mg) magnesium per 8.4 MJ (2000 kcal) for 78
days then replenished with magnesium by supplementing the diet with 200
mg magnesium as the gluconate per day for 58 days. If a subject
exhibited adverse heart rhythm changes before 78 days of depletion were
completed, she entered the repletion period early. SETTING: The
metabolic research unit of the Grand Forks Human Nutrition Research
Center. SUBJECTS: A total of 14 post menopausal women were recruited by
advertisement throughout the United States. Thirteen women (ages 47 to
75 years) completed the study. RESULTS: During magnesium depletion,
heart rhythm changes appeared in 5 women and resulted in 4 prematurely
entering the magnesium repletion period (42 to 64 days of depletion
instead of 78). Three women exhibited atrial fibrillation and flutter
that responded quickly to magnesium supplementation. Magnesium
deprivation resulted in a non-positive magnesium balance that became
highly positive with magnesium repletion. Magnesium deprivation
decreased red blood cell membrane magnesium, serum total cholesterol and
erythrocyte superoxide dismutase concentrations, increased the urinary
excretion of sodium and potassium, and increased serum glucose
concentration. CONCLUSIONS: Magnesium balance may be a suitable
indicator of magnesium depletion under experimental conditions.
Magnesium deficiency resulting from feeding a diet that would not be
considered having an atypical menu induces heart arrhythmias, impairs
glucose homeostasis, and alters cholesterol and oxidative metabolism in
post menopausal women. A dietary intake of about 4.12 mmol (100 mg)
Mg/8.4 MJ is inadequate for healthy adults and may result in compromised
cardiovascular health and glycemic control in post menopausal women.
PMID: 17536123 [PubMed - in process]
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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