[PHNUTR-L] ... beta-glucan enriched oat bran increases faecal
concentration of carboxylic acids in healthy subjects
fivestar at nutritionucanlivewith.com
Wed Jun 6 07:12:37 PDT 2007
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Eur J Clin Nutr. 2007 May 23; [Epub ahead of print]
Dietary supplementation with beta-glucan enriched oat bran
increases faecal concentration of carboxylic acids in healthy subjects.
Nilsson U, Johansson M, Nilsson A, Björck I, Nyman M.
1Applied Nutrition and Food Chemistry, Department of Food
Technology, Engineering and Nutrition, Center for Chemistry and Chemical
Engineering, Lund University, Lund, Sweden.
Background/Objective:Carboxylic acids (CAs), especially butyric
acid, have been suggested to counteract colonic diseases, such as
ulcerative colitis and colon cancer. Colonic formation of CAs can be
influenced by the diet, but the concentrations and pattern formed need
to be evaluated for different food products in humans. To elucidate how
the colonic concentration of CAs in healthy subjects is influenced by
dietary supplementation with oat bran, and whether the concentration
varies over time and during consecutive
days.Subjects/Methods:Twenty-five healthy subjects (age 24+/-1.3) were
recruited to the study. The subjects were given 40 g beta-glucan
enriched oat bran per day, corresponding to 20 g dietary fibre, in 4
slices of bread. CAs were analysed in faeces during three consecutive
days after 0, 4, 8 and 12 weeks on this diet.Results:The concentration
of acetic, propionic, butyric, isobutyric and isovaleric acid was higher
(P<0.05-0.001) after 8 weeks on the oat bran diet as compared with
values at entry, whereas that of lactic acid was lower (P<0.05). After
12 weeks, the concentrations of acetic, propionic and isobutyric acid
were still higher and that of lactic acid lower. The variation between
individuals was considerable, whereas in the same individuals there was
little variation.Conclusions:Oat bran increased the faecal concentration
of CAs after 8 weeks, indicating an increased concentration also in the
distal colon. The concentration of all main acids increased, except for
lactic acid, which decreased. Oat bran may therefore have a preventive
potential adjunct to colonic diseases.European Journal of Clinical
Nutrition advance online publication, 23 May 2007;
PMID: 17522598 [PubMed - as supplied by publisher]
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
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