[PHNUTR-L] Plasma Urate and Risk of Parkinson's Disease
fivestar at nutritionucanlivewith.com
Fri Jun 22 06:36:06 PDT 2007
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American Journal of Epidemiology Advance Access published online on
June 20, 2007
American Journal of Epidemiology, doi:10.1093/aje/kwm127
American Journal of Epidemiology Copyright © 2007 by the Johns Hopkins
Bloomberg School of Public Health All rights reserved; printed in U.S.A.
Plasma Urate and Risk of Parkinson's Disease
MG Weisskopf1,2, E O'Reilly2, H Chen3, MA Schwarzschild4 and A Ascherio2,5
1 Department of Environmental Health, Harvard School of Public Health,
2 Department of Nutrition, Harvard School of Public Health, Boston, MA
3 Epidemiology Branch, National Institute of Environmental Health
Sciences, Research Triangle Park, NC
4 Department of Neurology, Massachusetts General Hospital, Boston, MA
5 Department of Epidemiology, Harvard School of Public Health, Boston, MA
Correspondence to Dr. Marc G. Weisskopf, Department of Environmental
Health, Harvard School of Public Health, Landmark Center, Third Floor
East, P.O. Box 15697, Boston, MA 02215 (e-mail: mweissko at hsph.harvard.edu).
Received for publication December 11, 2006. Accepted for publication
March 13, 2007.
Oxidative stress contributes to dopaminergic neuron degeneration in
Parkinson's disease. Urate, a potent antioxidant, could be
neuroprotective. To determine whether higher plasma concentrations of
urate predict a reduced risk of Parkinson's disease, the authors
conducted a nested case-control study among participants in the Health
Professionals Follow-up Study, a cohort comprising over 18,000 men who
provided blood samples in 1993–1995. Eighty-four incident cases of
Parkinson's disease were diagnosed through 2000, and each was randomly
matched to two controls by year of birth, race, and time of blood
collection. Rate ratios of Parkinson's disease according to quartile of
uricemia were estimated by use of conditional logistic regression. The
mean urate concentration was 5.7 mg/dl among cases and 6.1 mg/dl among
controls (p = 0.01). After adjustment for age, smoking, and caffeine,
the rate ratio of Parkinson's disease for the highest quartile of
uricemia compared with the lowest was 0.43 (95% confidence interval:
0.18, 1.02; ptrend = 0.017). This association was stronger in analyses
excluding cases diagnosed within 4 years (median) from blood collection
(rate ratio = 0.17, 95% confidence interval: 0.04, 0.69; ptrend =
0.010). These results suggest that high plasma urate concentrations may
decrease the risk of Parkinson's disease, and they raise the possibility
that interventions to increase plasma urate may reduce the risk and
delay the progression of Parkinson's disease.
Parkinson disease; prospective studies; uric acid
Abbreviations: CI, confidence interval
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
"Eat well, stay well with Parkinson's disease"
"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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