[PHNUTR-L] l-Alanin-l-glutamine supplementation improves the
outcome after colorectal surgery for cancer
fivestar at nutritionucanlivewith.com
Thu Jun 28 20:52:18 PDT 2007
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Colorectal Dis. 2007 Jul;9(6):515-20.
l-Alanin-l-glutamine supplementation improves the outcome after
colorectal surgery for cancer.
Oguz M, Kerem M, Bedirli A, Mentes BB, Sakrak O, Salman B, Bostanci H.
Department of General Surgery, Medical Faculty, Gazi University,
Objective To investigate the effect of l-alanine-l-glutamine (Gln)
on postoperative complication rate and duration of hospitalization in
patients operated for colorectal cancer. Method A total of 109 patients
operated with the diagnosis of colorectal cancer and given enteral
nutrition between January 2001 and January 2005 were prospectively
analysed. The patients were randomized and analysed in two groups; Gln
group (n = 57): patients were given parenteral Gln (1 g/kg/day,
Dipeptiven, Fresenuis Kabi, Germany) together with enteral nutrition
(Ensure; Abbott, Zwolle, The Netherlands) and the control group (n = 52)
only received enteral nutrition (Ensure; Abbott), which was a standard
isonitrogenous and isocaloric formula. The supplemental enteral
nutrition was provided for at least 5 days pre- and postoperatively
according to the nutritional status of the patients. Age, gender,
subjective global assessment (SGA), body mass index (BMI), serum
albumin, protein, associated disorders, localization of pathology,
techniques of anastomosis, postoperative complications and length of
hospital stay were analysed for each patient. Results The duration of
nutritional support in the Gln group was 6 +/- 2 and 5 +/- 1 days pre-
and postoperatively; while it was 7 +/- 1 and 6 +/- 1 days for the
control group, and there were no significant difference among the groups
(P > 0.05). Age, gender, SGA, BMI, levels of serum albumin and protein,
localization of pathology and techniques of anastomosis were also
similar (P > 0.05). Wound infection (P = 0.038), intraabdominal abcess
formation (P = 0.044) and wound dehiscence (P = 0.044) were
significantly higher in the control group than in the Gln group. There
was no significant difference in terms of anastomotic leakage and other
complications between both groups (P > 0.05). Hospital stay was
significantly shorter in the Gln group (P < 0.001). Conclusion
Supplementation of parenteral Gln decreased the postoperative
complications and hospital stay and in the patients undergoing the
colorectal surgery for cancer.
PMID: 17573745 [PubMed - in process]
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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