[PHNUTR-L] More support for prebiotic, probiotics for colon health
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Sat Mar 10 05:25:40 PST 2007
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More support for prebiotic, probiotics for colon health
By Stephen Daniells
05/03/2007 - Daily intake of prebiotics and probiotics may reduce the
production of potentially toxic or carcinogenic compounds by suppressing
the activity of certain enzymes, says new research from Belgium.
"In view of the carcinogenic potential of these enzymes, the induced
changes that occurred in this study by lactulose, oligofructose-enriched
inulin, L. casei Shirota and B. breve on the bacterial
beta-glucuronidase activity could be considered as beneficial for the
host and may have important implications for health," wrote lead author
Vicky De Preter from University Hospital Gasthuisberg, Leuven.
Writing in the European Journal of Clinical Nutrition, the researchers
report the findings of their investigation into the potential benefits
of the prebiotics lactulose (Duphalac Solvay Pharma) and
oligofructose-enriched inulin (Raftilose Synergy 1, Orafti), and the
probiotics Lactobacillus casei Shirota (Yakult), Bifidobacterium breve
(Yakult) and Saccharomyces boulardii (Perenterol, Biodiphar) on the
activity and levels of the enzymes beta-glucuronidase and
beta-glucosidase on 53 healthy volunteers (age range 19-26).
Probiotics are bacteria found in the gut that are understood to have
health benefits. Prebiotics are ingredients that stimulate growth of
probiotics in the gut, and synbiotics are a combination of the two.
The subjects were randomly assigned to one of the five intervention
groups and crossed over after four weeks of intervention. A two-week
washout period separated the interventions. Faecal samples were
collected over a period of 72 hours at the start and end of the
De Preter reports that both prebiotics significantly decreased
beta-glucuronidase activity, as did the probiotics L. casei Shirota and
B. breve. S. boulardii was found to have no affect on the enzymes, they
On the other hand, the probiotic was found to increase the levels of
"Supplementation with the synbiotic did not appear to be more beneficial
than either compound alone," stated the researchers.
"Administration of lactulose, oligofructose-enriched inulin, L. casei
Shirota or B. breve resulted in a decrease of the beta-glucuronidase
activity, which is considered beneficial for the host," they concluded.
Talking exclusively to NutraIngredients.com, lead researcher Professor
Kristin Verbeke said that it was currently difficult to indicate the
relevance of the observations.
"First of all, we have performed our measurements in young, "healthy"
individuals and it is very difficult to render healthy people more
healthy. Secondly, we have shown that administration of pre- and
probiotics can decrease the activity of potential harmful bacterial
enzymes (and other parameters of colonic metabolism) but we have not
(yet) shown that people will live longer or healthier because of these
changes," said Prof. Verbeke.
"We should need large, long-term diet intervention studies to prove the
link between changes in colonic metabolism and health and this will be
Professor Verbeke also revealed that the research in ongoing with work
focusing on the evaluation of new potential pre- and probiotic substrates.
"We will [also] apply the methodology to patients in which an abnormal
colon metabolism is expected (such as inflammatory bowel disease and
irritable bowel disease). In this way, we want to investigate whether
similar changes on colonic metabolism are observed as in healthy
individuals and whether changes in colonic metabolism correlate with
changes in disease activity," said Prof. Verbeke.
"This would already be a first step in indicating the relevance of
colonic metabolism to health."
Source: European Journal of Clinical Nutrition
Advance online publication, doi: 10.1038/sj.ejcn.1602706
"Effect of dietary intervention with different pre- and probiotics on
intestinal bacterial enzyme activities"
Authors: V. De Preter, H. Raemen, L. Cloetens, E. Houben, P. Rutgeerts
and K. Verbeke
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
"Eat well, stay well with Parkinson's disease"
"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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