[PHNUTR-L] Lower Levels of Folate, B-12,
Higher Levels of Homocysteine Found Among Depressed Elderly
fivestar at nutritionucanlivewith.com
Tue Oct 16 19:04:54 PDT 2007
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Lower Levels of Folate and Vitamin B-12 and Higher Levels of
Homocysteine Found Among Depressed Elderly
Reference: "Correlation of folate, vitamin B12 and homocysteine plasma
levels with depression in an elderly Greek population," Dimopoulos N,
Piperi C, et al, Clin Biochem, 2007; 40(9-10): 604-608. (Address:
Laboratory of Biological Chemistry, University of Athens Medical School,
M. Asias 75, Goudi 11527, Athens, Greece. E-mail: dmpnikos at yahoo.gr ).
Summary: In a study involving 66 elderly subjects over 60 years of age,
subjects with depression were found to have lower plasma levels of
folate and vitamin B12 and higher plasma levels of homocysteine. Half
the subjects had depression (n=33) and the other half served as healthy
controls (n=33). All subjects were clinically evaluated and levels of
plasma folate, vitamin B12, and homocysteine were measured. Results
found significantly lower levels of folate and vitamin B12 and
significantly higher levels of homocysteine in the depressed subjects.
There were no significant differences in chronic diseases (such as
stroke, elevated cholesterol, high blood pressure, or diabetes) between
the two groups. Additional research needs to be carried out to assess
the impact of supplementation with folate and vitamin B12 on depression
in the elderly.
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
"Eat well, stay well with Parkinson's disease"
"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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