[PHNUTR-L] Soy Isoflavone Supplementation May Improve Fasting Glucose in Postmenopausal Women

[Kathrynne Holden]

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Topic: 	Soy Isoflavone Supplementation May Improve Fasting Glucose in 
Postmenopausal Women

http://www.vitasearch.com/CP/weeklyupdates/

Reference: 	"Soy isoflavone supplementation and fasting serum glucose 
and lipid profile among postmenopausal Chinese women: A double-blind, 
randomized, placebo-controlled trial," Ho SC, Chen Y, et al, Menopause, 
2007; 14(5): 905-912. (Address: Suzanne C. Ho, PhD, CUHK School of 
Public Health, Department of Community and Family Medicine, The Chinese 
University of Hong Kong, Hong Kong SAR. E-mail: suzanneho at cuhk.edu.hk ).

Summary: 	In a randomized, double-blind, placebo controlled trial 
involving 203 postmenopausal women aged 48-62 years, supplementation 
with soy isoflavones was found to favorably impact fasting serum glucose 
levels. The subjects were randomized to receive one of three treatments 
for a period of one year: 1) 40 mg/d soy isoflavones and 500 mg/d 
calcium (n=68); 2) 80 mg/d soy isoflavones and 500 mg/d calcium (n=68); 
3) 500 mg/d calcium and no isoflavones (placebo group, n=67). Results 
found that supplementation with soy isoflavones had a moderate but 
significantly favorable effect on fasting glucose levels. Compared with 
the placebo group, the one-year mean differences in fasting glucose 
changes were -5.2 mg/dL and -3.3 mg/dL in the 40 mg/d and 80 mg/d soy 
isoflavone groups. The effect of isoflavones was most significant in 
women whose baseline fasting glucose levels were 100 mg/dL or higher, as 
compared to women whose baseline fasting glucose levels were below 90 
mg/dL. No signifi cant changes in serum lipids (HDL cholesterol, LDL 
cholesterol, total cholesterol, triglycerides) were observed as a result 
of soy isoflavone supplementation. The authors conclude, "One-year of 
soy isoflavone supplementation might have a favorable effect on fasting 
glucose in women, but has no significant effect on serum lipids."
-- 
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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