[PHNUTR-L] Soy Isoflavone Supplementation May Improve Fasting
Glucose in Postmenopausal Women
fivestar at nutritionucanlivewith.com
Wed Oct 17 05:44:42 PDT 2007
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Topic: Soy Isoflavone Supplementation May Improve Fasting Glucose in
Reference: "Soy isoflavone supplementation and fasting serum glucose
and lipid profile among postmenopausal Chinese women: A double-blind,
randomized, placebo-controlled trial," Ho SC, Chen Y, et al, Menopause,
2007; 14(5): 905-912. (Address: Suzanne C. Ho, PhD, CUHK School of
Public Health, Department of Community and Family Medicine, The Chinese
University of Hong Kong, Hong Kong SAR. E-mail: suzanneho at cuhk.edu.hk ).
Summary: In a randomized, double-blind, placebo controlled trial
involving 203 postmenopausal women aged 48-62 years, supplementation
with soy isoflavones was found to favorably impact fasting serum glucose
levels. The subjects were randomized to receive one of three treatments
for a period of one year: 1) 40 mg/d soy isoflavones and 500 mg/d
calcium (n=68); 2) 80 mg/d soy isoflavones and 500 mg/d calcium (n=68);
3) 500 mg/d calcium and no isoflavones (placebo group, n=67). Results
found that supplementation with soy isoflavones had a moderate but
significantly favorable effect on fasting glucose levels. Compared with
the placebo group, the one-year mean differences in fasting glucose
changes were -5.2 mg/dL and -3.3 mg/dL in the 40 mg/d and 80 mg/d soy
isoflavone groups. The effect of isoflavones was most significant in
women whose baseline fasting glucose levels were 100 mg/dL or higher, as
compared to women whose baseline fasting glucose levels were below 90
mg/dL. No signifi cant changes in serum lipids (HDL cholesterol, LDL
cholesterol, total cholesterol, triglycerides) were observed as a result
of soy isoflavone supplementation. The authors conclude, "One-year of
soy isoflavone supplementation might have a favorable effect on fasting
glucose in women, but has no significant effect on serum lipids."
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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