[PHNUTR-L] Vitamin D supplementation and total mortality: a
meta-analysis of randomized controlled trials
fivestar at nutritionucanlivewith.com
Wed Oct 17 05:46:04 PDT 2007
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Vitamin D Intake May Reduce the Rate of Mortality
Reference: "Vitamin D supplementation and total mortality: a
meta-analysis of randomized controlled trials" Autier P, Gandini S,
Archives of Internal Medicine, 2007; 167(16): 1730-7. (Address:
International Agency for Research on Cancer, 150 cours Albert Thomas,
F-69372 Lyon, France. E-mail: Philippe Autier, MD, autierp at iacr.fr ).
Summary: In a review and meta-analysis of randomized controlled trials
examining the impact of vitamin D supplementation on risk of dying from
any health condition, supplementation with ordinary doses of vitamin D
was found to be associated with reduced rates of total mortality.
Eighteen independent, randomized, controlled trials involving a total of
57,311 subjects were identified through searches of PubMed, ISI Web of
Science, EMBASE, and the Cochrane Library for studies in any language.
Supplementation with vitamin D (either vitamin D2 or D3) ranged in
dosage from 300 to 2000 IU/day, depending on the study. The trial
size-adjusted mean daily dose was 528 IU/d. A total of 4,777 deaths from
any cause were found during a trial size-adjusted mean duration of 5.7
years. Significant differences in serum 25-hydroxyvitamin D were found
between the control and intervention groups in 9 of the studies (ranging
from a 1.4- to a 5.2-fold difference). The summary relative risk for
mortalit y from any cause was found to be 0.93. This risk did not change
regardless of whether calcium supplements were taken or not. These
results suggest that vitamin D supplementation in even ordinary doses
may help to reduce the risk of mortality. The authors conclude,
"Population-based, placebo-controlled randomized trials with total
mortality as the main end point should be organized for confirming these
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
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"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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