[PHNUTR-L] Potential Role of Vitamin D in the Treatment of
fivestar at nutritionucanlivewith.com
Thu Oct 18 06:40:50 PDT 2007
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Potential Role of Vitamin D in the Treatment of Tuberculosis
Reference: "A single dose of vitamin D enhances immunity to
mycobacteria," Martineau AR, Wilkinson RJ, et al, American Journal of
Respiratory and Critical Care Medicine, 2007; 176(2): 208-13. (Address:
Centre for Health Sciences, Queen Mary's School of Medicine and
Dentistry, Barts and The London, and Department of Clinical
Biochemistry, North West London Hospitals NHS Trust, Northwick Park
Hospital, Harrow, E1 2AT, UK. E-mail: a.martineau at qmul.ac.uk ).
Summary: In a randomized, double-blind, placebo-controlled trial
involving 192 healthy adult tuberculosis (TB) contacts living in London,
UK, supplementation with vitamin D was found to enhance the ability of
the subjects' blood to resist BCG-lux luminescence in vitro, thereby
improving its ability to resist mycobacteria. In the pre-antibiotic era,
vitamin D was used as a treatment for tuberculosis. In this study, the
researchers set out to determine the effect of vitamin D supplementation
on anti-mycobacterial immunity. Subjects were randomized to receive
either a single dose of vitamin D (2.5 mg) or a placebo. At follow up
(six weeks later), results found that the blood of subjects treated with
vitamin D had a much greater ability to restrict BCG-lux luminescence in
vitro, as compared to the placebo. Antigen-stimulated IFN-gamma
secretion remained unaffected by the treatment. These results suggest
that vitamin D supplementation may have a role to play in enhancing
anti-mycobac terial immunity. The authors conclude, "Clinical trials
should be performed to determine whether vitamin D supplementation
prevents reactivation of latent TB infection."
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
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