[PHNUTR-L] Plasma folate concentration and cognitive performance:
Rotterdam Scan Study
fivestar at nutritionucanlivewith.com
Sun Sep 16 07:12:54 PDT 2007
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Higher Plasma Folate Concentrations Associated with Better Cognitive
Reference: "Plasma folate concentration and cognitive performance:
Rotterdam Scan Study," de Lau LM, Breteler MMB, et al, Am J Clin Nutr,
2007; 86(3): 728-34. (Address: MMB Breteler, Department of Epidemiology
and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR
Rotterdam, Netherlands. E-mail: m.breteler at erasmusmc.nl ).
Summary: In a population-based, cross-sectional study involving 1,033
nondemented participants aged 60-90 years, results indicate that higher
plasma folate concentrations may be associated with better cognitive
performance, in particular, improved psychomotor speed. The participants
underwent extensive cognitive testing and brain imaging. Using
multivariate linear regression adjusted for confounders, every 1 SD
increase in plasma folate was associated with a +0.05 mean change in
global cognitive function test scores, a +0.08 mean change in
psychomotor speed test scores, and a +0.02 mean change in memory
function test scores. The association between plasma folate
concentrations and cognitive performance only slightly diminished after
further adjusting for homocysteine concentrations. Additionally, the
volume of subcortical white matter lesions and the presence of severe
white matter lesions decreased significantly with increasing plasma
folate concentration. Thus, the authors of t his study conclude, "Higher
plasma folate concentrations are associated with better global cognitive
function and better performance on tests of psychomotor speed,
regardless of homocysteine concentration. These associations may be
mediated by vascular mechanisms."
Kathrynne Holden, MS, RD < fivestar at nutritionucanlivewith.com >
"Ask the Parkinson Dietitian" http://www.parkinson.org/
"Eat well, stay well with Parkinson's disease"
"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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