[PHNUTR-L] Occupational Exposure to Nitrous Oxide May Negatively
Impact Vitamin B12 Status
fivestar at nutritionucanlivewith.com
Thu Feb 7 05:46:07 PST 2008
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Occupational Exposure to Nitrous Oxide May Negatively Impact Vitamin
Reference: "Impaired vitamin B12 metabolic status in healthcare workers
occupationally exposed to nitrous oxide," Krajewski W, Kucharska M, et
al, Br J Anaesth, 2007; 99(6): 812-8. (Address: Department of
Anaesthesia and Intensive Care Medicine, The Polish Mother Memorial
Hospital, Lodz, Poland).
Summary: In a study involving 95 operating room nurses with a history
of exposure to nitrous oxide and 90 unexposed counterparts, results
indicate that impaired vitamin B12 status is more prevalent among nurses
occupationally exposed to nitrous oxide. Vitamin B12 and homocysteine
(Hcy) were measured in all participants. Subjects exposed to nitrous
oxide showed lower vitamin B12 and higher Hcy levels than subjects
without exposure to nitrous oxide. Additionally, the decrease in vitamin
B12 levels was significantly greater in subjects exposed to nitrous
oxide in concentrations substantially exceeding occupational exposure
limit. Thus, the authors of this study conclude, "Exposure to N(2)O
[nitrous oxide] in healthcare workers is associated with alterations of
vitamin B12 metabolic status, the extent of which depends on the level
Kathrynne Holden, MS, RD
"Ask the Parkinson Dietitian" http://www.parkinson.org/
"Eat well, stay well with Parkinson's disease"
"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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