[PHNUTR-L] Supplementation with Probiotics May Enhance Eradication of H. Pylori

[Kathrynne Holden]

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	Supplementation with Probiotics May Enhance Eradication of H. Pylori
http://www.vitasearch.com/CP/weeklyupdates/

Reference: 	"The effect of probiotics on Helicobacter pylori 
eradication," Park SK, Park DI, et al, Hepatogastroenterology, 2007; 
54(79): 2032-6. (Address: Department of Internal Medicine, Kangbuk 
Samsung Hospital, Sungkyunkwan University School of Medicine, Jongno-gu, 
Seoul 110-746, Korea).

Summary: 	In a study involving 352 patients infected with Helicobacter 
pylori, supplementation with probiotics was found to improve drug 
compliance, reduce side effects, and enhance the intention-to-treat 
eradication rate of H. pylori. Subjects were randomized into 2 groups. 
One group received probiotics (bacillus subtilis and Streptococcus 
faecium) plus standard triple therapy (2 antibiotics plus a proton pump 
inhibitor), while the other group received standard triple therapy 
alone. Probiotics were given for 8 weeks. Four weeks after completion of 
therapy, results of intention to treat analysis found that subjects in 
the probiotics group experienced higher eradication of H. pylori 
(83.5%), compared to subjects in the triple therapy alone group (73.3%). 
Side effects of triple therapy, including diarrhea, were more common in 
the triple therapy alone group. Results of this study suggest that 
adding probiotic supplementation to standard pharmacological therapy 
used to treat H. pylor i infection ('triple therapy') may enhance 
eradication of H. pylori and reduce side effects, thereby rendering 
treatment more tolerable and effective.
-- 
Kathrynne Holden, MS, RD
"Ask the Parkinson Dietitian"  http://www.parkinson.org/
"Eat well, stay well with Parkinson's disease"
"Parkinson's disease: Guidelines for Medical Nutrition Therapy"
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